Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat
| Autor: | B.-M. Emanuelsson, E. Klasson Wehler, A. Sandholm |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Polybrominated Biphenyls Administration Oral Biological Availability Absorption (skin) Toxicology Biochemistry Gas Chromatography-Mass Spectrometry Decabromodiphenyl ether Rats Sprague-Dawley chemistry.chemical_compound Pharmacokinetics Halogenated Diphenyl Ethers Toxicokinetics Animals Tissue Distribution Biotransformation Distribution Volume Flame Retardants Pharmacology Chromatography Phenyl Ethers Half-life General Medicine Bioavailability Rats chemistry Injections Intravenous Solvents Steady state (chemistry) Bromobenzenes Half-Life |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 33(11) |
| ISSN: | 0049-8254 |
| Popis: | 1. The absorption of the flame retardant decabromodiphenyl ether (BDE-209) has been shown by its detection in human plasma, but reported experimental data on its determined in rat, and qualitative analyses by GC/MS of metabolites in plasma were performed. The relative amount of phenolic metabolites was determined in a rat plasma sample obtained after administration of radiolabelled BDE-209. 2. The bioavailability of parent BDE-209 was calculated to be about 26% in rat. The concentrations of phenolic radioactivity in plasma 3 and 7 days after dosing were four times higher than those of the neutral compounds, i.e. parent compound, indicating absorption in rat are inconsistent. The bioavailability and half-life were therefore that total absorption was higher than 26%. 3. Thirteen phenolic metabolites were determined in the plasma and the major phenolic metabolites were characterized as a hydroxy-octaBDE, a hydroxy-nonaBDE and a hydroxy-methoxy-hexaBDE (guaiacol-type). The exposure to the phenolic metabolites seemed higher than the parent compound, BDE-209. 4. The initial elimination phase in plasma t1/2alpha for BDE-209 was 2 h, implying a rapid distribution of BDE-209 to well-perfused tissues. The distribution volume at steady state was 1.4 l kg-1, implying a low tendency for distribution to adipose tissue. The terminal t1/2 for BDE-209 in the intravenously dosed rat was calculated as 2.5 days (58 h). |
| Databáze: | OpenAIRE |
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