Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove
| Autor: | Nelson Y. S. Lam, Tegan P. Stockdale, Ian Paterson, Matthew J. Anketell |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Engineering
business.industry Swinholide A Metals and Alloys Total synthesis Leiodermatolide General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Chivosazole F Spongistatin 1 Astrobiology Organic reaction Materials Chemistry Ceramics and Composites Treasure business |
| Zdroj: | Chemical Communications. 57:3171-3189 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | The structural complexity and biological importance of macrolide natural products has inspired the development of innovative strategies for their chemical synthesis. With their dense stereochemical content, high level of oxygenation and macrocyclic cores, we viewed the efficient total synthesis of these valuable compounds as an aspirational driver towards developing robust methods and strategies for their construction. Starting out from the initial development of our versatile asymmetric aldol methodology, this personal perspective reflects on an adventurous journey, with all its trials, tribulations and serendipitous discoveries, across the total synthesis, in our group, of a representative selection of six macrolide natural products of marine and terrestrial origin - swinholide A, spongistatin 1, spirastrellolide A, leiodermatolide, chivosazole F and actinoallolide A. |
| Databáze: | OpenAIRE |
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