Infection with HIV-2
| Autor: | David M. Markovitz, Paul J. Bock |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
biology Immunology Nucleic acid sequence virus diseases HIV Infections Simian immunodeficiency virus medicine.disease_cause medicine.disease biology.organism_classification Virology Virus Viral Proteins Infectious Diseases Retrovirus Acquired immunodeficiency syndrome (AIDS) Immunopathology HIV-2 Lentivirus medicine Humans Immunology and Allergy Viral disease Child |
| Zdroj: | AIDS. 15:S35-S45 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-200100005-00006 |
| Popis: | In 1985 a group of healthy Senegalese whose sera demonstrated much stronger antibody responses to simian immunodeficiency virus (SIV) than to the HIV type 1 (HIV-1) was first described [1]. In 1986 this new retrovirus was isolated which is now known as HIV type 2 (HIV-2) [23]. Although both HIV-1 and HIV-2 belong to the lentivirus subfamily and their genomic organization is similar [4] HIV-2 is only about 40% similar to HIV-1 in nucleotide sequence and is more closely related to SIV with approximately 75% (or greater see later) nucleotide sequence similarity [4--6]. Although both HIV-1 and HIV-2 can cause acquired immune deficiency syndrome aids the clinical and biological characteristics of infection with these two viruses show substantial differences as well as similarities [7]. In particular HIV-2 is less readily transmitted and is generally less pathogenic than is HIV-1 [89]. In this paper we review what is presently known about HIV-2. (excerpt) |
| Databáze: | OpenAIRE |
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