Paracetamol-induced hepatotoxicity at recommended dosage
| Autor: | S M Riordan, J Kurtovic |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Analgesic Brachytherapy Internal medicine Internal Medicine medicine Humans Liver damage Antipyretic Carcinoma Renal Cell Acetaminophen Chemotherapy business.industry Analgesics Non-Narcotic Middle Aged medicine.disease Anus Neoplasms Effective dose (pharmacology) Kidney Neoplasms Malnutrition Endocrinology Toxicity Female Chemical and Drug Induced Liver Injury Complication business medicine.drug |
| Zdroj: | Journal of internal medicine. 253(2) |
| ISSN: | 0954-6820 |
| Popis: | In patients who develop liver damage following moderate paracetamol overdose in the order of 5-10 g daily, recent fasting and nutritional impairment have been identified as key precipitants. Hepatotoxicity caused by paracetamol at recommended dosage, in the absence of exposure to enzyme-inducing drugs, has recently been described as an idiosyncratic phenomenon. The possible importance of fasting and malnutrition in this setting is uncertain. We report a severely malnourished 53-year-old woman who developed severe hepatotoxicity whilst receiving paracetamol at recommended dosage (4 g daily) following a period of fasting, in the absence of enzyme-inducing agents. Subsequent paracetamol exposure up to 2.6 g daily thrice weekly, in the setting of ongoing malnutrition and fasting as before, did not lead to recurrent liver damage. These findings indicate that paracetamol-related liver damage occurring within recommended dosage guidelines can be a dose-dependent rather than necessarily idiosyncratic phenomenon, at least in the setting of recent fasting and severe malnutrition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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