Triple-phase dynamic MRI: a new clue to predict malignant transformation of giant cell tumor of bone
| Autor: | Yong Lu, Xiao-Yi Ding, Liang Chen, Ming-Jue Si, Cheng-Sheng Wang, Lianjun Du |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Bone Neoplasms Sensitivity and Specificity Malignant transformation Lesion Image Interpretation Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging Malignant Giant Cell Tumor Giant Cell Tumor of Bone business.industry Significant difference Washout Reproducibility of Results General Medicine Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Cell Transformation Neoplastic Dynamic contrast-enhanced MRI Steep slope Female Radiology medicine.symptom business Giant-cell tumor of bone |
| Zdroj: | European journal of radiology. 83(2) |
| ISSN: | 1872-7727 |
| Popis: | Objective Our purpose was, through the comparison of the characteristics of time–intensity curve on triple-phase dynamic contrast-enhanced MRI among groups of giant cell tumor of bone (GCTB), recurrent benign giant cell tumor of bone (RBGCTB), and secondary malignant giant cell tumor of bone (SMGCTB), to find clues to predict the malignant transformation of GCTB. Subjects and methods 21 patients diagnosed as GCTB were included in this study. All cases took recurrence after intralesional curettage. 9 cases were confirmed as SMGCTB and 12 cases were confirmed as RBGCTB. Cases were divided into four groups: group A, GCTB ( n = 9); group B, SMGCTB ( n = 9); group C, GCTB ( n = 12); group D, RBGCTB ( n = 12). Enhancement index(EI) of lesions on DCEMRI was calculated using formula: EI( t ) = [ S ( t ) − S (0)]/ S (0), where S (0) was signal intensity of lesion on non-contrast-enhanced T1-weighted images and S ( t ) was signal intensity of lesion on DCEMRI ( t = 30, 60, 180 s). Enhancement index of each group in each phase was compared using One-Way ANOVA analysis. Slope values of time–intensity curve were compared by the same way. Results Time–intensity curve of SMGCTB was characterized by a steep upward slope followed by an early and rapid washout phase. Time–intensity curve of GCTB and RBGCTB was characterized by a steep slope followed by a relatively slow washout phase. No significant difference in enhancement index was found in the first phase ( p > 0.05). There was significant difference in the second and the third phase ( p p > 0.05). Conclusions Dynamic contrast-enhanced MRI appears a helpful method to find new clues to predict malignant transformation of GCTB. |
| Databáze: | OpenAIRE |
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