An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products†‡
| Autor: | Nicholas A. McGrath, Joshua R. Binner, Matthew Brichacek, Jon T. Njardarson, Georgios Markopoulos |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Biological Products
Bicyclic molecule Free Radicals Molecular Structure Chemistry Stereochemistry Terpenes Metals and Alloys Late stage Stereoisomerism General Chemistry Phloroglucinol Radical cyclization Desymmetrization Catalysis Article Surfaces Coatings and Films Electronic Optical and Magnetic Materials Bridged Bicyclo Compounds Cyclization Materials Chemistry Ceramics and Composites Computer Simulation Oxidation-Reduction |
| Popis: | Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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