The effect of 2-h infusion of 2-chlorodeoxyadenosine (cladribine) with prednisone in previously untreated B-cell chronic lymphocytic leukaemia
| Autor: | Tadeusz Robak, M Komarnicki, Trepińska E, E. Krykowski, Lech Konopka, Anna Dmoszynska, Aleksander B. Skotnicki, Jacek Roliński, M Kaźmierczuk, Wieslaw Nowak, Barbara Zdziarska, J. Hansz, I. Urasiński, Jerzy Z. Blonski, M Błasińska-Morawiec, S. Kotlarek-Haus |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.drug_class Chronic lymphocytic leukemia Antimetabolite Gastroenterology Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols Chlorodeoxyadenosine Humans Medicine Infusions Intravenous Cladribine Retrospective Studies business.industry Retrospective cohort study Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Survival Analysis Surgery Clinical trial Oncology Corticosteroid Female business medicine.drug |
| Zdroj: | European Journal of Cancer. 33:2347-2351 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(97)00349-3 |
| Popis: | 2-Chlorodeoxyadenosine (2-CdA) is a new antimetabolite chemotherapeutic agent active in indolent lymphoid malignancies. In this retrospective study, 69 previously untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL) were treated with 2-CdA administered at a dose of 0.12 mg/kg daily in 2-h intravenous infusion for 5 consecutive days. 45 patients also received prednisone 30 mg/m 2 orally each day for 5 days starting with 2-CdA courses. Patients were given 2–6 courses (mean 4.6) of 2-CdA repeated usually at monthly intervals. If a complete response was achieved, no further 2-CdA courses were administered. Guidelines for response were those developed by the NCI Sponsored Working Group. Complete response (CR) was achieved in 26 (38%) and partial response (PR) in 27 (39%) cases, giving an overall response rate of 77%. 16 patients (23%) did not respond to 2-CdA. In the subgroup of 45 patients receiving 2-CdA with prednisone, CR was obtained in 15 (33%) and PR in 20 (44%) patients giving an overall response rate of 78%. CR was achieved in 11 (46%) out of 24 patients treated only with 2-CdA and in 7 cases (29%) PR was observed, giving an objective response rate of 75%. The differences between both subgroups were not statistically significant. However, we observed a relationship between the response and the number of courses of 2-CdA given in patients receiving and those not receiving prednisone. In the subgroup receiving 2-CdA with prednisone, an earlier response to 2-CdA was observed. In this group a response was achieved in 9 (20%) patients after two courses of 2-CdA and in 18 (40%) after four courses. In the subgroup receiving only 2-CdA, 17 (71%) responses were obtained after six cycles. |
| Databáze: | OpenAIRE |
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