Hashimoto’s thyroiditis worsens ovaries in polycystic ovary syndrome patients compared to Anti-Müllerian hormone levels

Autor: Özer Birge, Feyza Tekeli, Aliye Nigar Serin, Aysel Uysal, Suheyla Gorar
Rok vydání: 2021
Předmět:
Adult
Anti-Mullerian Hormone
endocrine system
medicine.medical_specialty
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Autoimmunity
030209 endocrinology & metabolism
Ovary
Hashimoto Disease
Anti-Müllerian hormone
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Thyroiditis
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
Ovarian Reserve
Ovarian reserve
Polycystic ovary syndrome
lcsh:RC648-665
030219 obstetrics & reproductive medicine
biology
business.industry
Hashimoto’s thyroiditis
General Medicine
medicine.disease
Antral follicle
Polycystic ovary
female genital diseases and pregnancy complications
Anti-thyroid autoantibodies
Premature ovarian failure
Endocrinology
medicine.anatomical_structure
biology.protein
Female
business
Research Article
Zdroj: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Endocrine Disorders
ISSN: 1472-6823
Popis: Background The human ovary is the target of autoimmune attack in cases of autoimmune disorders, which can cause ovarian dysfunction. Due to the higher prevalence of Hashimoto’s Thyroiditis (HT) in Polycystic Ovary Syndrome (PCOS) patients, we aimed to evaluate ovarian reserve and the effect of autoimmune exposure time on ovarian reserve in PCOS patients with HT by Anti-Müllerian hormone (AMH) levels. Methods Forty-six PCOS patients and 46 PCOS with HT diagnosed patients who are between 18 and 35 years old were recruited for this study. Detailed medical histories were obtained from all participants. Polycystic ovary image was evaluated and antral follicles were counted by transvaginal ultrasound. Modified Ferriman Gallwey score, body mass index, waist/hip ratio of the patients were examined. Hormonal, biochemical profiles and AMH levels of the patients were evaluated during the early follicular phase. The data of both groups were statistically analyzed with SPSS 18.0. Results 20 (43.5%) patients in the PCOS group were fertile, 8 (17.4%) patients in the PCOS + HT group were fertile, fertility rate was significantly lower in PCOS + HT group. The mean AMH value was 8.8 ± 8.8 in the PCOS + HT group and 12.4 ± 8.1 in the PCOS group and it was significantly lower in the PCOS + HT group (p = 0.043). AMH values were significantly negatively correlated with anti-thyroid peroxidase antibody (anti-TPO) level and the duration of HT. There was a significant positive correlation between the anti-TPO level and the duration of HT. Conclusıon We pointed out that the coexistence of PCOS and HT, two prevalent diseases of reproductive age, further diminished ovarian reserve. More exposure of the ovaries to autoantibodies can cause ovarian destruction, similar to the thyroid gland like HT. Because of all these close relations with PCOS and thyroid dysfunctions, we recommend evaluating both thyroid autoantibodies and hormone levels in PCOS patients at the first visit. Patients with PCOS + HT should be monitored more closely to determine the fertility treatment options and control premature ovarian failure (POF) table.
Databáze: OpenAIRE
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