In Vivo Fluoride Ion Detection and Imaging in Mice Using a Designed Near-Infrared Ratiometric Fluorescent Probe Based on IR-780
| Autor: | Xinxin Tong, Xinwei Tian, Zhao Li, Dongyu Li, Qingjun Kong, Xingbin Yang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Fluorescence-lifetime imaging microscopy Indoles Biocompatibility Infrared Rays Flour 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Ion Fluorides chemistry.chemical_compound In vivo Animals Humans Fluorescent Dyes Detection limit Mice Inbred BALB C Chemistry Drinking Water Near-infrared spectroscopy Hep G2 Cells General Chemistry 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences 0210 nano-technology General Agricultural and Biological Sciences Fluoride |
| Zdroj: | Journal of Agricultural and Food Chemistry. 66:11486-11491 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | A ratiometric near-infrared fluorescence probe based on IR-780 is developed and applied to fluoride anion (F-) detection in potable water and white flour as well as fluorescence imaging in living cells and mice. The proposed probe not only displays a linear ratiometric (F740/F690 nm) fluorescence response but also possesses near-infrared wavelengths to F- with a detection limit of 0.2 μM. Moreover, the designed probe displays high selectivity toward F-, which makes it feasible for F- detection in potable water and white flour. More importantly, applied to monitor F- in living HepG2 cells and male BALB/c mice, the probe indicates good biocompatibility and low cytotoxicity. However, no study for F- detection has been reported by a ratiometric NIR fluorescent probe so far. We expect that this probe with superior properties has great potential for use in F- detection in biological systems and in vivo studies. |
| Databáze: | OpenAIRE |
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