Diagnostic impact of routine Lyme serology in recent-onset arthritis: results from the ESPOIR cohort
| Autor: | Sophie Varache, Dewi Guellec, Divi Cornec, Jean Pierre Daures, Alain Saraux, Sandrine Jousse-Joulin, Valérie Narbonne, Thierry Marhadour, Valérie Devauchelle-Pensec, Maxime Dougados |
|---|---|
| Přispěvatelé: | CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Department of Microbiology Brest, Department of Microbiology, Brest, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service de rhumatologie B, Université Paris Descartes - Paris 5 (UPD5), Department of Biostatistics Nimes, Clinical Research Institute Universiy of Montpellier, CHRU - Rhumatologie (CHRU - Rhumato), CHU Brest, Laboratoire d'Immunothérapies et Pathologies lymphocytaires B (EA2216), Université de Bretagne Occidentale (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
[SDV.IMM] Life Sciences [q-bio]/Immunology Epidemiology Inflammatory arthritis Immunology Arthritis Context (language use) Early Arthritis Lyme Arthritis Infections Serology 03 medical and health sciences 0302 clinical medicine Lyme disease Rheumatology Internal medicine medicine Immunology and Allergy 030212 general & internal medicine ComputingMilieux_MISCELLANEOUS 030203 arthritis & rheumatology business.industry medicine.disease 3. Good health LYME Cohort [SDV.IMM]Life Sciences [q-bio]/Immunology business |
| Zdroj: | RMD Open : Rheumatic & Musculoskeletal Diseases RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2016, 2 (1), ⟨10.1136/rmdopen-2015-000120⟩ RMD Open : Rheumatic & Muskuloskeletal Diseaeses RMD Open : Rheumatic & Muskuloskeletal Diseaeses, EULAR ; BMJ, 2016, 2 (1), <10.1136/rmdopen-2015-000120> RMD Open |
| ISSN: | 2056-5933 |
| DOI: | 10.1136/rmdopen-2015-000120⟩ |
| Popis: | Objectives Lyme disease may be considered by rheumatologists in patients with recent-onset arthritis, even in the absence of suggestive symptoms. The aim of this study was to determine the diagnostic impact of routine Lyme serology in a French cohort of patients with recent-onset arthritis affecting at least 2 joints. Methods We performed an ancillary study of a French prospective multicentre cohort established to monitor clinical, biological and radiographic data in patients with inflammatory arthritis in at least 2 joints, lasting for 6 weeks to 6 months. Borrelia IgM and IgG antibodies were sought routinely at baseline, using ELISA tests, independently from the physician's strategy for detecting a spirochetal infection. We recorded the proportion of patients with a final diagnosis of Lyme arthritis and evaluated the diagnostic performance of Lyme serology in this particular context. The clinical and biological characteristics of patients according to the Lyme serology results were analysed. Results Of 810 patients, 657 (81.1%) were negative for IgM and IgG antibodies, 91 (11.2%) had only IgM antibodies, 49 (6%) had only IgG antibodies, and 13 (1.6%) had IgG and IgM antibodies. Thus, 7.6% had IgG positivity, consistent with exposure to Borrelia infection. IgG positivity was significantly more prevalent in the North and North-East regions of France (χ2=14.6, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|