Sleep onset insomnia, daytime sleepiness and sleep duration in relationship toToxoplasma gondiiIgG seropositivity and serointensity
| Autor: | Zaki Ahmad, John W. Stiller, Claudia Gragnoli, Teodor T. Postolache, Christopher A. Lowry, Yara W. Moustafa, Mary Pavlovich, Soren Snitker, Beverly Fang, Dietmar Fuchs, Uttam K. Raheja, Sarra Nazem, Aline Dagdag |
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| Rok vydání: | 2017 |
| Předmět: |
insomnia
Clinical Biochemistry Excessive daytime sleepiness Biochemistry 03 medical and health sciences 0302 clinical medicine Immune system parasitic diseases Insomnia Medicine epworth sleepiness scale Crystallography biology toxoplasma gondii business.industry excessive daytime sleepiness Epworth Sleepiness Scale Toxoplasma gondii biology.organism_classification Sleep in non-human animals 030227 psychiatry QD901-999 Immunology Old Order Amish sleep duration Molecular Medicine Sleep onset medicine.symptom old order amish business 030217 neurology & neurosurgery |
| Zdroj: | Pteridines, Vol 28, Iss 3-4, Pp 195-204 (2017) |
| ISSN: | 2195-4720 0933-4807 |
| DOI: | 10.1515/pterid-2017-0010 |
| Popis: | Toxoplasma gondii(T. gondii) infects central nervous tissue and is kept in relative dormancy by a healthy immune system. Sleep disturbances have been found to precipitate mental illness, suicidal behavior and car accidents, which have been previously linked toT. gondii as well.We speculated that if sleep disruption, particularly insomnia, would mediate, at least partly, the link betweenT. gondiiinfection and related behavioral dysregulation, then we would be able to identify significant associations between sleep disruption andT. gondii. The mechanisms for such an association may involve dopamine (DA) production byT. gondii, or collateral effects of immune activation necessary to keepT. gondiiin check. Sleep questionnaires from 2031 Old Order Amish were analyzed in relationship toT. gondii-IgG antibodies measured by enzyme-linked immunosorbent assay (ELISA).Toxoplasma gondiiseropositivity and serointensity were not associated with any of the sleep latency variables or Epworth Sleepiness Scale (ESS). A secondary analysis identified, after adjustment for age group, a statistical trend toward shorter sleep duration in seropositive men (p=0.07). In conclusion, it is unlikely that sleep disruption mediates links betweenT. gondiiand mental illness or behavioral dysregulation. Trending gender differences in associations betweenT. gondiiand shorter sleep need further investigation. |
| Databáze: | OpenAIRE |
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