Detection of Chlamydia trachomatis antigens in urine as an alternative to swabs and cultures
| Autor: | lain Stewart, Max Chemesky, William Seidelman, Lorna Grant, John W. Sellors, James B. Mahony, Ian Cunningham, Corinne Devlin, Stephan J. Landis, Santina Castriciano |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Fluorescent Antibody Technique Chlamydia trachomatis Urine Immunologic Tests medicine.disease_cause Microbiology Immunoenzyme Techniques Antigen Predictive Value of Tests Urethral Diseases medicine Immunology and Allergy Humans Chlamydiaceae Gynecology Antigens Bacterial Chlamydia biology medicine.diagnostic_test Chlamydia Infections biology.organism_classification medicine.disease Infectious Diseases Urethra medicine.anatomical_structure Evaluation Studies as Topic Chlamydiales Immunoassay Female |
| Zdroj: | The Journal of infectious diseases. 161(1) |
| ISSN: | 0022-1899 |
| Popis: | By using commercially available spectrophotometric and immunofluorescent immunoassays, Chlamydia trachomatis antigens were detected in first-void urine (FVU) sediments from 224 men attending a sexually transmitted disease clinic at a frequency of 81.6%-86.8% compared with 86.8% (33/38) positive by urethral swab culture (P less than .05). Endocervical cultures from 228 women attending a gynecology clinic yielded 92.3% (12/13) positive compared with 61.5%-76.9% for urine samples in three antigen-detection assays. Culturing urine from either gender yielded low positivity rates (23.7% for men, 15.4% for women). Defining truly infected patients as positive by culture or by any two of the three antigen tests, all assays were 100% specific. Immunodiagnostic testing of male FVU sediment appears to be a reliable, rapid, nontraumatic method for diagnosing chlamydia infection. |
| Databáze: | OpenAIRE |
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