Murepavadin: a new antibiotic class in the pipeline
| Autor: | Glenn E. Dale, Antoni Torres, Ignacio Martin-Loeches |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Drug medicine.drug_class Peptidomimetic media_common.quotation_subject 030106 microbiology Antibiotics Pharmacology Peptides Cyclic Microbiology law.invention 03 medical and health sciences law Drug Resistance Multiple Bacterial Virology medicine Animals Humans Pseudomonas Infections Pathogen media_common Clinical pharmacology business.industry Antimicrobial Anti-Bacterial Agents Disease Models Animal Infectious Diseases Mechanism of action Pseudomonas aeruginosa Efflux medicine.symptom business |
| Zdroj: | Expert Review of Anti-infective Therapy. 16:259-268 |
| ISSN: | 1744-8336 1478-7210 |
| DOI: | 10.1080/14787210.2018.1441024 |
| Popis: | With the increase in multi-drug resistant P. aeruginosa, antimicrobials with a novel mechanism of action are needed that can target these infections. Areas covered: Intravenous murepavadin is in Phase 3 development for the treatment of HABP/VABP due to P. aeruginosa. This paper summarizes the available information on the discovery, the in vitro activity, pharmacokinetic and pharmacodynamic properties and the clinical pharmacology of murepavadin to date. Expert commentary: P. aeruginosa has an intrinsic resistance to many antibiotics due to high cellular impermeability and efficient drug efflux mechanisms, and the recent increase in prevalence of multidrug-resistant P. aeruginosa infections are particularly threatening in ICU settings. Murepavadin is a pathogen specific antimicrobial peptidomimetic with a novel, non-lytic mechanism of action, and is the first in class of outer membrane protein targeting antibiotics which are being developed. Murepavadin displays a potent in vitro activity including carbapenemase-producing and colistin-resistant P. aeruginosa. Murepavadin is active in pre-clinical animal models including infections with XDR isolates. The Pharmacokinetics is well characterized including subjects with impaired renal function and patients with VABP. Intravenous murepavadin is currently under clinical development for the treatment of HABP/VABP due to P. aeruginosa infection. |
| Databáze: | OpenAIRE |
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