Second trimester angiotensing-converting enzyme and uterine artery Doppler as predictors of preeclampsia in a high-risk population

Autor:	José A. Noguera-Velasco, Ana Martínez-Ruiz, Isabel Tovar-Zapata, Joaquín Pérez-Fornieles, María Desamparados Sarabia-Meseguer, Juan Luis Delgado-Marín, Juan Antonio Vílchez
Rok vydání:	2015
Předmět:	Adult medicine.medical_specialty Population Urology Peptidyl-Dipeptidase A Pulsatility index Sensitivity and Specificity Preeclampsia Cohort Studies Pre-Eclampsia Pregnancy Second trimester Surveys and Questionnaires Internal Medicine medicine Humans Cutoff Prospective Studies education Gynecology education.field_of_study business.industry Uterine artery doppler Obstetrics and Gynecology Ultrasonography Doppler medicine.disease Uterine Artery Pregnancy Trimester Second Gestation Female business Biomarkers Blood sampling
Zdroj:	Hypertension in Pregnancy. 34:171-180
ISSN:	1525-6065 1064-1955
Popis:	Objective: To investigate whether serum angiotensing-converting enzyme (ACE) and uterine artery Doppler (UAD) are useful markers as predictors of preeclampsia (PE) in a high-risk population. Methods: Patients at risk of PE (n = 68) were subclassified as having PE (n =8 ) or no PE (n = 60). Blood samples were obtained between 19 and 22 weeks of gestation. Doppler ultrasound of the uterine arteries was done at the time of blood sampling. Maternal serum ACE was determined through spectrophotometry assay (A15 Biosystem, ATOM, Barcelona, Spain). Results: Comparing the group who presented PE with the one who was not developed it, we found significant differences for ACE (54.2 ± 21.2, 38.1 ± 12.3 U/L; p = 0.003); the pulsatility index (PI) (1.2 ± 0, 3.1 ± 0.3; p = 0.032) and resistance index (RI) (0.7 ± 0.1, 0.5 ± 0.1; p = 0.004). The AUC for ACE was 0.724, so we selected the cutoff of 36.5 U/L (sensitivity: 62.5% and specificity: 86.7%). The AUC for PI was 0.652 choosing a cutoff of 1.4 (sensitivity: 57.1% and specificity: 93.1%). The AUC for RI was 0.712 and the cutoff of 0.7 (sensitivity of 71.4% and specificity: 89.6%). The combination that allowed us to increase the diagnostic performance was the ACE+RI with Doppler study, increasing the AUC to 0.872. Conclusions: ACE, PI and RI as parameters of Doppler study were useful predictors of PE in the second trimester of gestation. The best combination to increase the diagnostic performance was ACE with the RI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd28c0ae05bf23de6caea6242f20224 https://doi.org/10.3109/10641955.2014.988352 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.