Association of statin use and development of renal dysfunction in type 2 diabetes—The Hong Kong Diabetes Registry
| Autor: | Ronald C.W. Ma, Vanessa W. S. Ng, Xilin Yang, Risa Ozaki, Linda W. Yu, Andrea O.Y. Luk, Winnie W. Y. Lau, Peter C.Y. Tong, Wing-Yee So, Juliana C.N. Chan, Francis C.C. Chow, Alice P. Kong |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Renal function Type 2 diabetes Cohort Studies Endocrinology Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Prospective Studies Registries Risk factor Prospective cohort study Aged Dyslipidemias business.industry Hazard ratio General Medicine Middle Aged medicine.disease Treatment Outcome Diabetes Mellitus Type 2 Cohort Physical therapy Hong Kong Female Kidney Diseases Hydroxymethylglutaryl-CoA Reductase Inhibitors business Follow-Up Studies Glomerular Filtration Rate Cohort study |
| Zdroj: | Diabetes Research and Clinical Practice. 88:227-233 |
| ISSN: | 0168-8227 |
| Popis: | Aim Dyslipidaemia may be a risk factor for diabetic kidney disease. We examined prospectively association between the use of statins and development of renal dysfunction in type 2 diabetes. Methods A consecutive cohort of 5264 diabetic patient recruited between 1996 and 2005 underwent detailed assessments. Renal dysfunction was defined as first estimated glomerular filtration rate 2 , or, the first hospitalisation with a diagnosis of renal disease as coded by the International Classification of Disease, Ninth Revision. Drug use was quantified using the proportion of exposure time from baseline to event/death/censored time, as appropriate. Results In this cohort (male: 47.3%, median age: 55 years, median duration of diabetes: 6.0 years), none had renal dysfunction at baseline. During a median follow-up period of 4.9 (quartiles: 2.77, 7.04) years, 703 patients (13.4%) developed renal dysfunction, 1275 patients (22.2%) were exposed to statins. After controlling for baseline risk factors, multivariable adjusted hazard ratio of statin use for development of renal dysfunction was 0.32 (95% CI 0.21–0.50, p Conclusion Use of statins was associated with reduced risk of developing renal dysfunction in type 2 diabetes and this association was independent of baseline risk factors. |
| Databáze: | OpenAIRE |
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