A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers
Autor: | Zheng-Tao Zhao, Rui-Ding Li, Wen-Xuan Zheng, Ning Meng, Wen-Jun Zhu, Quanyang Li, Qin-Ren Zhang, Xiao-Lin Liang, Li-Hua Mei |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Lactobacillus casei
Lactobacillus casei LTL1879 Physiology Gut flora law.invention Superoxide dismutase Probiotic chemistry.chemical_compound healthy young people law Lactobacillus Medicine TX341-641 oxidant Bifidobacterium Nutrition and Dietetics biology gut microbiota business.industry blood biochemical Nutrition. Foods and food supply Clostridium leptum food and beverages biology.organism_classification Malondialdehyde chemistry probiotics inflammation biology.protein business Food Science |
Zdroj: | Nutrients, Vol 13, Iss 3891, p 3891 (2021) Nutrients Volume 13 Issue 11 |
ISSN: | 2072-6643 |
Popis: | Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus  casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p < 0.0001), while malondialdehyde (MDA) levels decreased (p < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (p < 0.05, respectively). Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p < 0.05), while Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors. |
Databáze: | OpenAIRE |
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