The roles of inflammation and immune mechanisms in Alzheimer's disease
| Autor: | Barry D. Greenberg, Linda J. Van Eldik, Reinhold Mueller, Dominik Feuerbach, Richard Margolin, Lisa J. Bain, Patricia E. Cole, Maria C. Carrillo, Richard M. Ransohoff, Nick Kozauer, Donna M. Wilcock, Matthew E. Kennedy, James Hendrix, Kelly R. Bales, José Luis Molinuevo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Central nervous system Adaptive immunity Inflammation Disease Review Article Biology 03 medical and health sciences 0302 clinical medicine Neuroinflammation medicine Immune mechanisms Innate immunity Innate immune system Microglia Alzheimer's disease Acquired immune system 3. Good health Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Immunology Neurology (clinical) medicine.symptom Astrocyte Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Translational Research & Clinical Interventions |
| ISSN: | 2352-8737 |
| DOI: | 10.1016/j.trci.2016.05.001 |
| Popis: | The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed. |
| Databáze: | OpenAIRE |
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