Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework

Autor:	Wei-Lun Pan, Yong Tan, Wei Meng, Nai-Han Huang, Yi-Bang Zhao, Zhi-Qiang Yu, Zhong Huang, Wen-Hua Zhang, Bin Sun, Jin-Xiang Chen
Rok vydání:	2021
Předmět:	Cell Membrane Biophysics Bioengineering Breast Neoplasms Hydrogen Peroxide Biomaterials Photochemotherapy Mechanics of Materials Cell Line Tumor Neoplasms Ceramics and Composites Tumor Microenvironment Ferroptosis Humans Female Metal-Organic Frameworks
Zdroj:	Biomaterials. 283
ISSN:	1878-5905
Popis:	Designing and developing nanomedicine based on the tumor microenvironment (TME) for effective cancer treatment is highly desirable. In this work, polyvinyl pyrrolidone (PVP) dispersed nanoscale metal-organic framework (NMOF) of Fe-TCPP (TCPP = tetrakis (4-carboxyphenyl) porphyrin) loaded with hypoxia-activable prodrug tirapazamine (TPZ) and coated by the cancer cell membrane (CM) is constructed (the formed nanocomposite denoted as PFTT@CM). Due to the functionalization with the homologous cancer cell membrane, PFTT@CM is camouflaged to evade the immune clearance and preferentially accumulates at the tumor site. Once internalized by cancer cells, PFTT@CM is activated by the TME through redox reaction and Fenton reaction between Fe
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd0527f109360b9642a89e7cff73e17 https://pubmed.ncbi.nlm.nih.gov/35247637 Zobrazit plný text záznamu Full Text from ScienceDirect