Influenza A (H1N1)-induced ischemic stroke in a child: Case report and review of the literature
| Autor: | Antonio Chiaretti, Luca Massimi, Piero Valentini, Pietro Ferrara, Francesca Priolo, Manuela Ceccarelli, Roberta Calzedda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pediatrics
medicine.medical_specialty viruses Critical Care and Intensive Care Medicine Virus Cerebrospinal fluid H1N1 influenza virus Medicine Respiratory system Interleukin 6 Stroke Children Cause of death Ischemic stroke biology business.industry Interleukins Influenza a medicine.disease children interleukins ischemic stroke Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Immunology Emergency Medicine biology.protein business influenza |
| Zdroj: | Signa vitae : journal for intesive care and emergency medicine Volume 9 Issue 2 |
| ISSN: | 1334-5605 1845-206X |
| Popis: | Ischemic stroke is an important cause of death and long term morbidity in children. Viral respiratory infections are emerging as important risk factors responsible for ischemic stroke in this age group. The direct action of virus against cerebral vessels, autoimmune reactivity, and increased production of cytokines are advocated as the main factors for causing ischemic stro-ke. This study can be useful for clarifying some molecular aspects of H1N1 virus infection in children.We report on the case of a H1N1-induced ischemic stroke in a Caucasian 2 year-old female. The cerebrospinal fluid samples showed the positivity of polymerase chain reaction for influenza A (H1N1) infection, confirmed also by pharyngeal swab culture. Increased levels of cerebrospinal fluid interleukin 6 and interleukin 1β were also detected. H1N1 virus infection has been identified as an important cause of neurological involvement in children. The findings of increased levels of Interleukin 6 and interleukin 1β in the cerebrospinal fluid of this child with H1N1 induced-ischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. |
| Databáze: | OpenAIRE |
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