Baseline and post-atrial pacing release of atrial natriuretic factor in mitral stenosis
| Autor: | L S, Malatino, B, Stancanelli, G, Greco, G, Polizzi, C, Leonardi, G, Russo, C, Tamburino, G, Giuffrida, G, Tamburino |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Blood Pressure Internal medicine Mitral valve medicine.artery medicine Humans Mitral Valve Stenosis Sinus rhythm Heart Atria Pulmonary Wedge Pressure cardiovascular diseases Atrium (heart) Pulmonary wedge pressure Cardiac catheterization business.industry Myocardium Cardiac Pacing Artificial Central venous pressure Middle Aged medicine.disease medicine.anatomical_structure Heart failure Pulmonary artery cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor |
| Zdroj: | American Heart Journal. 119:97-101 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/s0002-8703(05)80088-2 |
| Popis: | To investigate the release of atrial natriuretic factor (ANF) in mitral stenosis and the influence of the increase on the frequency of atrial contraction or atrial distention on ANF secretion, we studied 10 patients with symptoms of congestive heart failure (New York Heart Association classes II and III) in sinus rhythm, who were undergoing cardiac catheterization as part of an evaluation workup for mitral stenosis. Echocardiographic tracings, repeat determinations of mean pulmonary artery wedge pressure (MPAWP) and mean right atrial pressure, and blood sampling from the pulmonary artery for measurements of ANF were performed at baseline, during atrial pacing (pacing rate of 125 beats/min for 5 minutes), and 5 minutes after the pacing protocol was completed. Baseline ANF levels were closely related to right atrial pressure (r = 0.89; p less than 0.001) and increased markedly after atrial pacing from 205.6 +/- 39.8 (SEM) to 343.9 +/- 57.9 (SEM) pg/ml. A similar pacing-induced increase was shown for MPAWP and left atrial size. Our data indicate that pacing-induced increases in atrial distention and intracavitary pressure further stimulate release of ANF. However, an independent effect of frequency of atrial pacing on plasma ANF in humans could not be identified. |
| Databáze: | OpenAIRE |
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