Biomarkers Utility: At the Borderline between Cardiology and Neurology
| Autor: | Cosmina Elena Ciobanu, Cezara Bobric, Ivona Mitu, Bogdan Huzum, Ovidiu Mitu, Celina Stafie, Alexandru Dan Costache, Adriana Ion, Stefania Teodora Duca, Dan Iliescu Halitchi, Irina Iuliana Costache, Roxana Troase |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology troponin business.industry neurology biomarkers Review Clinical judgment stroke cardiovascular diseases Clinical Practice Copeptin RC666-701 cardiology Internal medicine medicine Cardiology Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics business BNP |
| Zdroj: | Journal of Cardiovascular Development and Disease Journal of Cardiovascular Development and Disease, Vol 8, Iss 139, p 139 (2021) |
| ISSN: | 2308-3425 |
| DOI: | 10.3390/jcdd8110139 |
| Popis: | Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations. |
| Databáze: | OpenAIRE |
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