Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria
| Autor: | Kim R. Hardie, Agnès Vendeville, Christoph M. Tang, Karin Heurlier, Klaus Winzer |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Salmonella typhimurium
Microbial metabolism Virulence Biology medicine.disease_cause Models Biological Microbiology chemistry.chemical_compound Methionine Bacterial Proteins Escherichia coli medicine Animals Humans Pathogen Vibrio Regulation of gene expression Genetics Bacteria General Immunology and Microbiology Pathogenic bacteria biology.organism_classification Autoinducer-2 Carbon-Sulfur Lyases Quorum sensing Infectious Diseases chemistry |
| Zdroj: | Nature Reviews Microbiology. 3:383-396 |
| ISSN: | 1740-1534 1740-1526 |
| Popis: | Bacteria exploit many mechanisms to communicate with each other and their surroundings. Mechanisms using small diffusible signals to coordinate behaviour with cell density (quorum sensing) frequently contribute to pathogenicity. However, pathogens must also be able to acquire nutrients and replicate to successfully invade their host. One quorum-sensing system, based on the possession of LuxS, bears the unique feature of contributing directly to metabolism, and therefore has the potential to influence both gene regulation and bacterial fitness. Here, we discuss the influence that LuxS and its product, autoinducer-2, have on virulence, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved. |
| Databáze: | OpenAIRE |
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