The Superoxide Dismutase Mimetic, Tempol, Reduces the Bioavailability of Nitric Oxide and does not Alter L-NAME-Induced Hypertension in Rats
| Autor: | Ivanita Stefanon, Dalton Valentim Vassallo, Valdeci da Cunha, Silvio César Preti |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Endothelium Biological Availability Blood Pressure Pharmacology Nitric Oxide Toxicology Nitric oxide Cyclic N-Oxides Superoxide dismutase Phenylephrine chemistry.chemical_compound Pharmacokinetics medicine Animals Rats Wistar Aorta biology Superoxide Dismutase General Medicine Rats NG-Nitroarginine Methyl Ester Blood pressure medicine.anatomical_structure chemistry Anesthesia Toxicity cardiovascular system biology.protein Spin Labels Endothelium Vascular Acetylcholine medicine.drug |
| Zdroj: | Basic Toxicology. 97:29-34 |
| ISSN: | 1742-7843 1742-7835 |
| Popis: | L-NAME-induced hypertension is characterized by chronic inhibition of nitric oxide synthesis. We have investigated if tempol, an agent mimicking superoxide dismutase might reduce hypertension and the increased vascular reactivity to pressor agents. Rats were divided into: Control, animals receiving L-NAME 50 mg kg(-1)day(-1), tempol 200 mg kg(-1)day(-1) and tempol plus L-NAME. Drugs were administrated in the drinking water for seven days. L-NAME increased mean arterial blood pressure (Control: 108+/-3 mmHg versus L-NAME 181+/-5 mmHg; P |
| Databáze: | OpenAIRE |
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