Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection
| Autor: | Hu Hanjian, Yu Zhang, Wen-Zhao Chen, Chusong Zhou, Gang-Biao Jiang, Xia-Xiao Wu, Zhu Shuirong, Wei-Xiong Li, Zeng-Lin Li, Tian Hu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Alginates Antibiotics Composite number 02 engineering and technology Bone tissue Biochemistry Tigecycline Bone and Bones 03 medical and health sciences Structural Biology Spectroscopy Fourier Transform Infrared medicine Escherichia coli Human Umbilical Vein Endothelial Cells Humans Viability assay Particle Size Cytotoxicity Molecular Biology 030304 developmental biology Cell Proliferation Ions 0303 health sciences biology Chemistry Aerogel General Medicine Bacterial Infections 021001 nanoscience & nanotechnology biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Delayed-Action Preparations Microscopy Electron Scanning 0210 nano-technology Antibacterial activity Gels Bacteria Copper Nuclear chemistry |
| Zdroj: | International journal of biological macromolecules. 167 |
| ISSN: | 1879-0003 |
| Popis: | Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases. In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications. The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days. The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity. Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%). These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect