Structural, functional and pH sensitive release characteristics of water-soluble polysaccharide from the seeds of Albizia lebbeck L
| Autor: | Chekuri Ashok Kumar Varma, K. Jayaram Kumar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Albizia lebbeck
Polymers and Plastics Rhamnose Albizzia 02 engineering and technology Xylose Polysaccharide 01 natural sciences Dosage form Excipients chemistry.chemical_compound Polysaccharides Spectroscopy Fourier Transform Infrared Materials Chemistry Monosaccharide Food science chemistry.chemical_classification Drug Carriers Chromatography biology 010405 organic chemistry Organic Chemistry Monosaccharides Water Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Drug Liberation chemistry Galactose Seeds 0210 nano-technology Drug carrier |
| Zdroj: | Carbohydrate polymers. 175 |
| ISSN: | 1879-1344 |
| Popis: | Plant polysaccharides, generally regarded as safe (GRAS), are gaining importance as excipients in drug delivery. Therefore, the current paper presents the studies on structural, functional and drug release study of water soluble polysaccharide (ALPS) from seeds of Albizia lebbeck L. High swelling, water holding capacity, foam stability and lower moisture content suggests its use as additive in food preparations. The apparent molecular weight of polysaccharide was found to be 1.98×102kDa. Monosaccharide composition analysis indicated that ALPS consists of mannose (4.06%), rhamnose (22.79%), glucose (38.9%), galactose (17.84%) and xylose (16.42%). Micromeritic properties revealed that the polysaccharide possess potential for pharmaceutical applications. From the surface charge analysis, ALPS was found to be non-ionic polysaccharide. Morphological study reveals the polysaccharide with irregular particle shape and rough surface. Fourier transformed infrared spectroscopy (FTIR) study confirms the carbohydrate nature of polysaccharide. From the thermogravimetric analysis (TGA) data, the second mass loss (243-340°C) attributed to polysaccharide degradation. The drug release profile reveals the use of polysaccharide for the preparation of pH sensitive pharmaceutical dosage forms. |
| Databáze: | OpenAIRE |
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