Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine
| Autor: | Ingrid Castberg, Andreas Austgulen Westin, Olav Spigset, Eirik Skogvoll |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Olanzapine medicine.medical_specialty Adolescent Population 030226 pharmacology & pharmacy Age and gender Benzodiazepines Quetiapine Fumarate Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Internal medicine medicine Humans education Clozapine Aged Aged 80 and over education.field_of_study Risperidone medicine.diagnostic_test Norway Age Factors Middle Aged Serum concentration 030227 psychiatry Psychiatry and Mental health Therapeutic drug monitoring Anesthesia Quetiapine Female Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica |
| Popis: | Objective To investigate serum concentrations of second-generation antipsychotics in relation to age and gender in a population ranging from 18 to 100 years. Method Results from a routine therapeutic drug monitoring database were retrieved, and 43 079 samples from 11 968 patients were included (17 249 samples for clozapine, 16 171 samples for olanzapine, 5343 samples for risperidone, and 4316 samples for quetiapine). The dose-adjusted concentration was used as the primary target variable. A linear mixed model was used to allow the inclusion of multiple samples from each patient. Results Age had a significant impact on the concentrations of all four drugs. At the age of 80, the dose-adjusted concentrations were up to twice those of the age of 40. At the age of 90, dose-adjusted concentrations were two- to three-fold higher. Age-related increases were largest for clozapine (+108% at 80 years; +197% at 90 years) and smallest for olanzapine (+28% at 80 years; +106% at 90 years). Females generally had dose-adjusted concentrations 20–30% higher than males. Conclusion The effect of age on the serum concentrations of the antipsychotics studied becomes pronounced with advanced age. The patient population aged above 70 should be subdivided according to exact age, and considerable dose reductions are recommended. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the article, locked until 2 September 2018 due to copyright restrictions. It has been published in final form at http://dx.doi.org/10.1111/acps.12794. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Databáze: | OpenAIRE |
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