Inflammatory markers in bronchoalveolar lavage fluid of Standardbred racehorses with inflammatory airway disease: response to interferon-alpha
| Autor: | D. S. Mcvey, S. Krakowka, Cummins Jm, J. T. Robertson, Moore Br |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Immunoglobulin A Time Factors Respiratory Tract Diseases Administration Oral Alpha (ethology) Alpha interferon 6-Ketoprostaglandin F1 alpha Antiviral Agents Dinoprostone Immunoglobulin G Double-Blind Method Oral administration Albumins medicine Animals Humans Horses Dose-Response Relationship Drug medicine.diagnostic_test biology business.industry Interferon-alpha Proteins Horse General Medicine respiratory system Blood proteins respiratory tract diseases Bronchoalveolar lavage Immunology biology.protein Eicosanoids Female Horse Diseases business Bronchoalveolar Lavage Fluid Sports |
| Zdroj: | Equine Veterinary Journal. 29:142-147 |
| ISSN: | 2042-3306 0425-1644 |
| DOI: | 10.1111/j.2042-3306.1997.tb01656.x |
| Popis: | Protein and eicosanoid concentrations and procoagulant activity were determined in bronchoalveolar lavage fluid (BALF) from 32 Standardbred racehorses with inflammatory airway disease (IAD) and 6 control horses. Total protein, albumin and immunoglobulin G (IgG) concentrations were high (P < 0.05) in the BALF from horses with IAD, a finding consistent with exudation of plasma protein into the airway. Immunoglobulin A (IgA) concentrations also were increased (P < 0.05) which may signify local immunoglobulin production. Difference was not detected in prostaglandin E2 and 6-ketoprostaglandin F1 alpha concentrations in BALF of IAD-affected and control horses. Procoagulant activity was identified in the majority (66%) of BALF samples from IAD-affected horses and was not detected in control horses. Natural human interferon-alpha (nHulFN alpha) (placebo, 50, 150, or 450 units) was administered orally for 5 days to IAD-affected horses in a double-blind, randomised block design. Total protein, IgG, and IgA concentrations in BALF were reduced (P < 0.05) 8 days after administration of 50 u and 150 u nHuIFN alpha, and 15 days after administration of 50 u nHuIFN alpha. Procoagulant activity and albumin concentrations in BALF were lower 8 days after administration of 50 u nHuIFN alpha. Oral administration of low-dose nHuIFN alpha appeared to ameliorate these parameters of lower respiratory tract inflammation in Standardbred racehorses with IAD. |
| Databáze: | OpenAIRE |
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