Screening of latent TB infection in patients with recently diagnosed bronchogenic carcinoma
| Autor: | Rasha Mokhtar EL-Nagar, Fatma M. F. Akl, Heba Wagih Abdelwahab, Mohammed Shehta, Marwa O. Elmaria, Dalia Abdellateif Abdelghany, Ahmed Ehab, Nesrine Saad Farrag, Mohamed Farouk Akl |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Tuberculosis Risk Assessment 03 medical and health sciences 0302 clinical medicine Latent Tuberculosis Risk Factors Pulmonary tuberculosis Internal medicine Prevalence Carcinoma Global health Humans Medicine In patient Aged 030304 developmental biology 0303 health sciences Latent tuberculosis business.industry Smoking General Medicine Middle Aged medicine.disease Active tuberculosis Bronchogenic carcinoma Carcinoma Bronchogenic 030220 oncology & carcinogenesis Egypt Female Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | Asian Cardiovascular and Thoracic Annals. 29:208-213 |
| ISSN: | 1816-5370 0218-4923 |
| Popis: | Background Cancer and pulmonary tuberculosis are major global health concerns and are associated with substantial morbidity and mortality. The association between active tuberculosis and subsequent cancer development has been investigated for many years. This study was planned to determine the prevalence of latent tuberculosis infection in patients with recently diagnosed bronchogenic carcinoma. Methods Sixty-four newly diagnosed primary lung cancer patients were enrolled. Diagnosis of latent tuberculosis infection was performed with QuantiFERON-TB Gold In-Tube tests, with exclusion of active tuberculosis. Results Latent tuberculosis infection was detected in 16 (25%) patients, and 8 (12.5%) had indeterminate results of the QuantiFERON-TB Gold In-Tube test. Being a current smoker was associated with a higher prevalence of latent tuberculosis ( p = 0.001). Comorbidities, tumor site, and histopathology were not associated with latent tuberculosis infection. Conclusions There is a considerable risk of concurrent latent tuberculosis in newly diagnosed primary bronchogenic carcinoma. The need for treatment of latent tuberculosis in these patients and its influence on the outcome and prognosis are issues for further investigations. |
| Databáze: | OpenAIRE |
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