Characterization of the in vivo cardiac electrophysiologic effects of high-dose cocaine in closed-chest, anesthetized dogs with normal hearts
| Autor: | José Roberto Otobone, Marcos Reis, Angelo Amato Vincenzo de Paola, Júlio Cesar Uchoa, José Luiz Gomes do Amaral, Guilherme Fenelon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Refractory period cocaine QT interval Electrocardiography QRS complex Dogs Bolus (medicine) In vivo Internal medicine Animals Medicine Anesthesia Anesthetics Local PR interval business.industry Hemodynamics Heart medicine.disease electrophysiology ventricular fibrillation Blood pressure lcsh:RC666-701 Ventricular fibrillation Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arquivos Brasileiros de Cardiologia, Vol 81, Iss 1, Pp 29-34 (2003) Arquivos Brasileiros de Cardiologia, Volume: 81, Issue: 1, Pages: 29-34, Published: JUL 2003 Arquivos Brasileiros de Cardiologia v.81 n.1 2003 Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
| ISSN: | 1678-4170 |
| Popis: | To characterize the cardiac electrophysiologic effects of cocaine.In 8 dogs (9-13 kg), electrophysiologic parameters and programmed stimulation were undertaken using transvenous catheters at baseline, and after cocaine intravenous infusion (12 mg/kg bolus followed by 0.22 mg/kg/min for 25 minutes).Cocaine plasma levels (n=5) rose to 6.73 +/- 0.56 mg/mL. Cocaine did not affect sinus cycle length and arterial pressure. Cocaine prolonged P wave duration (54 +/- 6 vs 73 +/- 4 ms, P0.001), PR interval (115 +/- 17 vs 164 +/- 15 ms, P0.001), QRS duration (62 +/- 10 vs 88 +/- 14 ms, P0.001), and QTc interval (344 +/- 28 vs 403 +/- 62 ms, P=0.03) but not JT interval (193 +/- 35 vs 226 +/- 53 ms, NS). Cocaine prolonged PA (9 +/- 6 vs 23 +/- 8 ms, P0.001), AH (73 +/- 16 vs 92 +/- 15 ms; P=0.03), and HV (35 +/- 5 vs 45 +/- 3 ms; P0.001) intervals and Wenckebach point (247 +/- 26 vs 280 +/- 28 ms, P=0.04). An increase occurred in atrial (138 +/- 8 vs 184 +/- 20 ms; P0.001) and ventricular (160 +/- 15 vs 187 +/- 25 ms; P=0.03) refractoriness at a cycle length of 300 ms. Atrial arrhythmias were not induced in any dog. Ventricular fibrillation (VF) was induced in 2/8 dogs at baseline and 4/8 dogs after cocaine.High doses of cocaine exert significant class I effects and seem to enhance inducibility of VF but not of atrial arrhythmias. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|