Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study
| Autor: | Joseph S. Ross, Vasilis Vasiliou, Sanket S. Dhruva, Anita T. Luxkaranayagam, John P. A. Ioannidis, Joshua D. Wallach, Patrick Liu |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Age subgroups Psychological intervention lcsh:Medicine 030204 cardiovascular system & hematology law.invention 03 medical and health sciences Age Distribution 0302 clinical medicine Randomized controlled trial law Intervention (counseling) Health care Epidemiology medicine Humans Clinical significance 030212 general & internal medicine Randomized Controlled Trials as Topic business.industry lcsh:R Precision medicine Heterogeneity of treatment effects Age Factors General Medicine 3. Good health Epidemiologic Studies Review Literature as Topic Subgroup analyses Research Design Data Interpretation Statistical Epidemiologic Research Design Family medicine Multiple comparisons problem Female business Research Article |
| Zdroj: | BMC Medicine BMC Medicine, Vol 17, Iss 1, Pp 1-11 (2019) |
| ISSN: | 1741-7015 |
| DOI: | 10.1186/s12916-019-1420-8 |
| Popis: | Background There is growing interest in evaluating differences in healthcare interventions across routinely collected demographic characteristics. However, individual subgroup analyses in randomized controlled trials are often not prespecified, adjusted for multiple testing, or conducted using the appropriate statistical test for interaction, and therefore frequently lack credibility. Meta-analyses can be used to examine the validity of potential subgroup differences by collating evidence across trials. Here, we characterize the conduct and clinical translation of age-treatment subgroup analyses in Cochrane reviews. Methods For a random sample of 928 Cochrane intervention reviews of randomized trials, we determined how often subgroup analyses of age are reported, how often these analyses have a P Results Among 928 Cochrane intervention reviews, 189 (20.4%) included plans to conduct age-treatment subgroup analyses. The vast majority (162 of 189, 85.7%) of the planned analyses were not conducted, commonly because of insufficient trial data. There were 22 reviews that conducted their planned age-treatment subgroup analyses, and another 3 reviews appeared to perform unplanned age-treatment subgroup analyses. These 25 (25 of 928, 2.7%) reviews conducted a total of 97 age-treatment subgroup analyses, of which 65 analyses (in 20 reviews) had non-overlapping subgroup levels. Among the 65 age-treatment subgroup analyses, 14 (21.5%) did not report any formal interaction testing. Seven (10.8%) reported P Conclusion Age-treatment subgroup analyses in Cochrane intervention reviews were frequently planned but rarely conducted, and implications of detected interactions were not discussed in the reviews or mentioned in common clinical resources. When subgroup analyses are performed, authors should report the findings, compare the results to previous studies, and outline any potential impact on clinical care. |
| Databáze: | OpenAIRE |
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