Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects
| Autor: | Robin L. Cotter, Raisa Persidsky, Y. Persidsky, Susan Swindells, Howard E. Gendelman, Anuja Ghorpade, Spring Holter, Kathleen Borgmann |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Immunology HIV Infections Neuropathology Biology Pathogenesis Basal (phylogenetics) Immune system HIV Seronegativity medicine Immunology and Allergy Macrophage Dementia Humans Inflammation Microglia Brain Middle Aged medicine.disease medicine.anatomical_structure Neurology Giant cell HIV-1 Female Neurology (clinical) |
| Zdroj: | Journal of neuroimmunology. 163(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Microglial and macrophage infection and immune activation underlie the pathogenesis of HIV-1-associated dementia (HAD). To assess microglial function in HAD, we isolated cells from brain tissues recovered from an HIV-1-infected patient within 4 h of death. Brain tissue from seronegative patients served as controls. Regional neuropathology was correlated to microglial function. HIV-1-patient microglia formed multinucleated giant cells and produced progeny virions. These microglia secreted reduced basal and LPS-stimulated TNF-alpha levels compared to controls. Monocytes from seronegative donors paralleled these diminished immune responses following repeated LPS-activation. These results demonstrate changes in innate microglial function following viral infection or chronic immune activation. |
| Databáze: | OpenAIRE |
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