Enhanced production of a self-toxic antibiotic xinghaiamine A from the novel marine-derived species Streptomyces xinghaiensis by resin addition
| Autor: | Yumei Wang, Xin-Qing Zhao, Xiang Geng, Wen-Ce Jiao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Aquatic Organisms
Time Factors medicine.drug_class Antibiotics Streptomyces xinghaiensis Bioengineering Microbial Sensitivity Tests Biology medicine.disease_cause Antibiotic production Applied Microbiology and Biotechnology Streptomyces Microbiology Anti-Bacterial Agents Resins Synthetic Alkaloids Staphylococcus aureus Fermentation medicine Adsorption Biotechnology |
| Zdroj: | Journal of bioscience and bioengineering. 117(2) |
| ISSN: | 1347-4421 |
| Popis: | An addition of 3% (w/v) adsorbent resin HP-20 at 3 days post-inoculation significantly improved xinghaiamine A production from 0.35 to 3.4 mg/L and shortened fermentation time from 18 to 9 days. Self-cytotoxicity of xinghaiamine A was verified and the minimal inhibitor concentration was estimated to be 8 μg/mL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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