Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
Autor: | da Silva Filipe, Ana, Shepherd, James G., Williams, Thomas, Hughes, Joseph, Aranday-Cortes, Elihu, Asamaphan, Patawee, Ashraf, Shirin, Balcazar, Carlos, Brunker, Kirstyn, Campbell, Alasdair, Carmichael, Stephen, Davis, Chris, Dewar, Rebecca, Gallagher, Michael D., Gunson, Rory, Hill, Verity, Ho, Antonia, Jackson, Ben, James, Edward, Jesudason, Natasha, Johnson, Natasha, McWilliam Leitch, E. Carol, Li, Kathy, MacLean, Alasdair, Mair, Daniel, McAllister, David A., McCrone, John T., McDonald, Sarah E., McHugh, Martin P., Morris, A. Keith, Nichols, Jenna, Niebel, Marc, Nomikou, Kyriaki, Orton, Richard J., O’Toole, Áine, Palmarini, Massimo, Parcell, Benjamin J., Parr, Yasmin A., Rambaut, Andrew, Rooke, Stefan, Shaaban, Sharif, Shah, Rajiv, Singer, Joshua B., Smollett, Katherine, Starinskij, Igor, Tong, Lily, Sreenu, Vattipally B., Wastnedge, Elizabeth, Holden, Matthew T. G., Robertson, David L., Templeton, Kate, Thomson, Emma C., Bashton, Matthew, Nelson, Andrew, Smith, Darren, Young, Greg, The COVID-19 Genomics UK (COG-UK) consortium |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Viral epidemiology Immunology Genome Viral Applied Microbiology and Biotechnology Microbiology law.invention Herd immunity 03 medical and health sciences law Intensive care Epidemiology Quarantine medicine Genetics Humans Author Correction Phylogeny 030304 developmental biology Aged 0303 health sciences Molecular Epidemiology Travel Molecular epidemiology 030306 microbiology Transmission (medicine) SARS-CoV-2 Outbreak COVID-19 High-Throughput Nucleotide Sequencing Cell Biology Middle Aged C700 Europe Geography Spain Mainland Demography |
Zdroj: | Nature Microbiology da Silva Filipe, A, Shepherd, J G, Williams, T, Hughes, J, Aranday-Cortes, E, Asamaphan, P, Ashraf, S, Balcazar, C, Brunker, K, Campbell, A, Carmichael, S, Davis, C, Dewar, R, Gallagher, M D, Gunson, R, Hill, V, Ho, A, Jackson, B, James, E, Jesudason, N, Johnson, N, McWilliam Leitch, E C, Li, K, MacLean, A, Mair, D, McAllister, D A, McCrone, J T, McDonald, S E, McHugh, M P, Morris, A K, Nichols, J, Niebel, M, Nomikou, K, Orton, R J, O'Toole, Á, Palmarini, M, Parcell, B J, Parr, Y A, Rambaut, A, Rooke, S, Shaaban, S, Shah, R, Singer, J B, Smollett, K, Starinskij, I, Tong, L, Wastnedge, E, Holden, M T G, Robertson, D L & Templeton, K 2020, ' Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland ', Nature Microbiology, vol. 6, no. 1, pp. 112-122 . https://doi.org/10.1038/s41564-020-00838-z |
ISSN: | 2058-5276 |
DOI: | 10.1038/s41564-020-00838-z |
Popis: | Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020. Epidemiological analysis confirmed that early introductions of SARS-CoV-2 originated from mainland Europe (the majority from Italy and Spain). We identified subsequent early outbreaks in the community, within healthcare facilities and at an international conference. Community transmission occurred after 2 March, 3 weeks before control measures were introduced. Earlier travel restrictions or quarantine measures, both locally and internationally, would have reduced the number of COVID-19 cases in Scotland. The risk of multiple reintroduction events in future waves of infection remains high in the absence of population immunity. |
Databáze: | OpenAIRE |
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