Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations
| Autor: | Kristina Björklund-Bodegård, José Boggia, Dirk G. Dechering, Masahiro Kikuya, Ahmet Adiyaman, Lutgarde Thijs, Tine W. Hansen, Yan Li, Theo Thien, Eamon Dolan, Christian Torp-Pedersen, Lars Lind, Takayoshi Ohkubo, Yutaka Imai, Jan A. Staessen, Ji-Guang Wang, Eoin O'Brien, Hans Ibsen, Edgardo Sandoya, Tom Richart |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Mean arterial pressure medicine.medical_specialty Percentile China Health aging / healthy living [IGMD 5] Ambulatory blood pressure Diastole Vascular medicine and diabetes [UMCN 2.2] 030204 cardiovascular system & hematology Sensitivity and Specificity White People 03 medical and health sciences 0302 clinical medicine Asian People Japan Predictive Value of Tests Risk Factors Internal medicine Internal Medicine Medicine Humans 030212 general & internal medicine Aged Cardiovascular diseases [NCEBP 14] business.industry Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Prognosis Surgery Europe Blood pressure Quartile Ambulatory Hypertension Multivariate Analysis Arterial stiffness Cardiology Regression Analysis Uruguay Female business |
| Zdroj: | Hypertension, 52, 1038-44 Hypertension; Vol 52 Hypertension, 52, 6, pp. 1038-44 Hypertension |
| ISSN: | 0194-911X |
| Popis: | The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects ( r 2 ) impacts on the association of AASI with established determinants of the relation between diastolic and systolic blood pressures. We constructed the International Database on the Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (7604 participants from 6 countries). AASI was unity minus the regression slope of diastolic on systolic blood pressure in individual 24-hour ambulatory recordings. AASI correlated positively with age and 24-hour mean arterial pressure and negatively with body height and 24-hour heart rate. The single correlation coefficients and the mutually adjusted partial regression coefficients of AASI with age, height, 24-hour mean pressure, and 24-hour heart rate increased from the lowest to the highest quartile of r 2 . These findings were consistent in dippers and nondippers (night:day ratio of systolic pressure ≥0.90), women and men, and in Europeans, Asians, and South Americans. The cumulative z score for the association of AASI with these determinants of the relation between diastolic and systolic blood pressures increased curvilinearly with r 2 , with most of the improvement in the association occurring above the 20th percentile of r 2 (0.36). In conclusion, a better fit of the AASI regression line enhances the statistical power of analyses involving AASI as marker of arterial stiffness. An r 2 value of 0.36 might be a threshold in sensitivity analyses to improve the stratification of cardiovascular risk. |
| Databáze: | OpenAIRE |
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