Not just heads and tails: The complexity of the sperm epigenome
| Autor: | Victor G. Corces, Yoon Hee Jung, Hannah B. Gold |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Biochemistry Chromatin remodeling Epigenesis Genetic 03 medical and health sciences Animals Humans Epigenetics Spermatogenesis Molecular Biology biology Thematic Minireviews Cell Biology Epigenome Chromatin Assembly and Disassembly Sperm Protamine Spermatozoa Cell biology Chromatin 030104 developmental biology Histone CTCF Fertilization biology.protein Paternal Inheritance |
| Popis: | Transgenerational inheritance requires mechanisms by which epigenetic information is transferred via gametes. Canonical thought holds that mammalian sperm chromatin would be incapable of carrying epigenetic information as post-translational modifications of histones because of their replacement with protamine proteins. Furthermore, compaction of the sperm genome would hinder DNA accessibility of proteins involved in transcriptional regulation and genome architecture. In this Minireview, we delineate the paternal chromatin remodeling events during spermatogenesis and fertilization. Sperm chromatin is epigenetically modified at various time points throughout its development. This allows for the addition of environment-specific modifications that can be passed from parents to offspring. |
| Databáze: | OpenAIRE |
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