Evolutionary divergence of the oncogenes GLI, HST and INT2
| Autor: | Robert A. Conte, Ram S. Verma, Rhea V. Samonte |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pan troglodytes
Hominidae Fibroblast Growth Factor 3 Fibroblast Growth Factor 4 Zinc Finger Protein GLI1 Pongo pygmaeus Proto-Oncogene Proteins Genetics medicine Homologous chromosome Animals Humans In Situ Hybridization Fluorescence Phylogeny Genetics (clinical) Chromosome 12 Chromosomal inversion Oncogene Proteins Chromosomes Human Pair 12 Gorilla gorilla biology medicine.diagnostic_test Phylogenetic tree Chromosomes Human Pair 11 Chromosome Mapping Chromosome biology.organism_classification Biological Evolution Fibroblast Growth Factors Homo sapiens Trans-Activators Transcription Factors Fluorescence in situ hybridization |
| Zdroj: | Heredity. 81:10-13 |
| ISSN: | 1365-2540 0018-067X |
| DOI: | 10.1046/j.1365-2540.1998.00362.x |
| Popis: | Almost a quarter of a century ago, the banding patterns of human and other higher primate chromosomes were compared, creating a barrage of speculation. Consequently, a number of approaches have been used to understand human descent. Chromosome modifications are believed to be important in the origin of species, and pericentric inversions account for the majority of evolutionary chromosomal alterations seen in Hominoidea. A comparative mapping fluorescence in situ hybridization technique, using locus-specific DNA probes as phylogenetic markers, was used to decipher the pericentric inversions of human chromosomes 11 and 12. Human-derived (Homo sapiens, HSA) DNA probes for GLI, HST and INT2 proto-oncogenes were used to identify their homologous locations in the chromosomes of chimpanzee (Pan troglodytes, PTR), gorilla (Gorilla gorilla, GGO) and orangutan (Pongo pygmaeus, PPY). The INT2 and HST loci mapping results confirm the earlier putative claim that a pericentric inversion took place in HSA chromosome 11 and its equivalent PTR and GGO chromosomes. In addition, these data provide additional information regarding the orangutan's position on the evolutionary tree of Pongidae and Hominidae. GLI mapping reveals that a pericentric inversion occurred in the HSA chromosome 12 equivalent in PTR and GGO, but was not seen in HSA or PPY. These pericentric inversions in PTR and GGO may have occurred at a period when both PTR and GGO had branched off from the Hominoidae trunk. The use of loci-specific probes to decipher pericentric inversions has proved to be a formidable approach in characterizing chromosome rearrangements and providing further evidence on human descent. |
| Databáze: | OpenAIRE |
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