Is survival in myeloid malignancies really improving? A retrospective 15-year population-based study
| Autor: | Marc Saez, Natalia Lloveras, David Gallardo, Rafael Marcos-Gragera, Gemma Osca-Gelis, Ramon Guardia, Montserrat Puig-Vives |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Time Factors Myeloid Population Kaplan-Meier Estimate Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Internal medicine Outcome Assessment Health Care medicine Humans Registries education Survival rate Aged Retrospective Studies education.field_of_study Myeloproliferative Disorders Relative survival business.industry Myelodysplastic syndromes Myeloid leukemia Imatinib Hematology Middle Aged Prognosis medicine.disease Cancer registry Survival Rate medicine.anatomical_structure Leukemia Myeloid Spain Hematologic Neoplasms Myelodysplastic Syndromes Population Surveillance Acute Disease Immunology Female business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 56:896-902 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2014.947610 |
| Popis: | Myeloid malignancies (MMs) are heterogeneous groups of diseases which present different prognoses. Using data from the population-based Girona Cancer Registry, we estimated the relative survival (RS) rates and relative excess risk of death among patients with MMs in the province of Girona between 1994 and 2008. The 5-year RS rate was 49.7%, ranging from 20.2% for acute myeloid leukemia (AML) to 75.3% for myeloproliferative neoplasms (MPN). Marked differences in RS were observed when the age of patients was considered: an increase in RS was mainly found in younger patients with myelodysplastic syndromes and MPN. Furthermore, cases of chronic myeloid leukemia treated with imatinib had a significantly better outcome compared with those that were untreated. Despite the slight improvement in the survival rate of younger patients with AML, RS remained stable for 15 years, as no significant improvements were made in the management of the disease during that period. |
| Databáze: | OpenAIRE |
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