The neurologist's approach to cerebral infarct and transient ischaemic attack in patients receiving anticoagulant treatment for non-valvular atrial fibrillation: ANITA-FA study
| Autor: | Á. Ximénez-Carrillo, Pedro Cardona, Sonia Quintas, Laura Llull, M Castellanos Rodrigo, José Vivancos, L. Benavente Fernández, M M Freijo Guerrero, A. García Pastor, Jose Antonio Egido, J. Serena, Jaime Masjuan, Gustavo Zapata-Wainberg, M Martínez Zabaleta |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment 03 medical and health sciences Therapeutic approach 0302 clinical medicine Modified Rankin Scale Internal medicine Epidemiology Atrial Fibrillation medicine Secondary Prevention Humans 030212 general & internal medicine Prospective Studies Registries Stroke Aged Aged 80 and over business.industry Anticoagulant Anticoagulants Atrial fibrillation Thrombolysis Cerebral Infarction medicine.disease Hospitalization Neurology Ischemic Attack Transient Observational study Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | European journal of neurology. 26(2) |
| ISSN: | 1468-1331 |
| Popis: | BACKGROUND AND PURPOSE The aim of this study was to describe the clinical and epidemiological characteristics of acute ischaemic stroke (AIS) in patients with atrial fibrillation (AF) previously treated with oral anticoagulants (OACs) according to the type of OAC prescribed. Also, to analyze the outcomes of the patients and the therapeutic approach adopted by the neurologist in the acute phase and for secondary prevention. METHODS We performed a multicenter, observational study based on prospective registries. We included patients with AF treated with OACs admitted for AIS over a 1-year period. Detailed clinical data and functional outcome at 3 months (modified Rankin Scale score) were collected. Patients were divided into two groups according to their pre-AIS anticoagulant therapy: vitamin K antagonists (AIS-VKA) and direct-acting OACs (AIS-DOAC). RESULTS We recruited 1240 patients (80.4% AIS-VKA and 19.6% AIS-DOAC). In the AIS-DOAC group, transient ischaemic attack was more frequent (18.1% vs. 10.8%; P = 0.001), symptomatic hemorrhagic transformation was less frequent (1.6% vs. 4.6%; P = 0.035) and hospital stay was shorter (median 6 vs. 7 days; P = 0.03). Intravenous thrombolysis was more commonly used in AIS-VKA (9.2% vs. 1.6%; P |
| Databáze: | OpenAIRE |
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