Behavioral effects in mice of postnatal exposure to low-doses of 137-cesium and bisphenol A
| Autor: | Luis Heredia, Victoria Linares, Montserrat Bellés, Maria Isabel Llovet, José L. Domingo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Bisphenol A Time Factors Physiology Anxiety Motor Activity Toxicology Ionizing radiation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols Plasticizers Animals Medicine Motor activity Benzhydryl compounds Benzhydryl Compounds Maze Learning Postnatal day Spatial Memory Postnatal brain Memory Disorders Behavior Animal Dose-Response Relationship Drug urogenital system business.industry Low dose Age Factors Brain Internal radiation Dose-Response Relationship Radiation Mice Inbred C57BL 030104 developmental biology Animals Newborn chemistry Cesium Radioisotopes business 030217 neurology & neurosurgery |
| Zdroj: | Toxicology. 340:10-16 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/j.tox.2015.12.002 |
| Popis: | Bisphenol A (BPA) is the most important plasticizer used in many household products such as polycarbonate plastics or epoxy resins. Public and scientific concerns exist regarding the possibility that the neonatal exposure to BPA may contribute to neurobehavioral disorders. On the other hand, there is little information on the effects of low doses of ionizing radiation during critical phases of postnatal brain development, as well as the combination of radiation and environmental chemicals. In this study, C57BL/6J mice were exposed to low doses of internal radiation ((137)Cs), and/or BPA on postnatal day 10 (PND10). At the age of two months, animals were submitted to several tests to assess anxiety, activity, learning, and memory. Results showed that exposure to (137)Cs, alone or in combination with BPA, increased the anxiety-like of the animals without changing the activity levels. Animals exposed to (137)Cs showed impaired learning, and spatial memory, an impairment that was not observed in the groups co-exposed to BPA. |
| Databáze: | OpenAIRE |
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