Comparison of first and second kidney transplants from the same deceased donor
| Autor: | Danilo Schmidt, Frank Friedersdorff, H.-H. Neumayer, Lutz Liefeldt, Markus Giessing, Tom Florian Fuller, Klemens Budde, Serdar Deger |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Renal function Subgroup analysis Kidney Expanded Criteria Donor Young Adult chemistry.chemical_compound medicine Humans Child Aged Retrospective Studies Aged 80 and over Transplantation Creatinine business.industry Incidence Cold Ischemia Graft Survival Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery chemistry Nephrology Child Preschool Female Hemodialysis business Glomerular Filtration Rate Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 25:4055-4061 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfq338 |
| Popis: | Background. Cold ischaemic time (CIT) may negatively influence graft function, increase the risk of acute rejection, and have adverse effects on graft and patient survival. This holds true especially for expanded criteria donors. As multi-centre studies on the impact of CIT are potentially biased, we performed a retrospective single-centre analysis of both kidneys from the same deceased donor transplanted consecutively into two recipients. Methods. A retrospective analysis of 80 kidneys from 40 donors transplanted into 80 recipients between January 1989 and December 2007 was conducted. Transplantations were performed successively due to logistic reasons resulting in a longer CIT for the second transplantation. We compared the outcome of the first (Rank 1) vs. the second (Rank 2) transplantation of the same donor. Ten donors/20 kidneys were allocated in the Eurotransplant Senior Program (ESP). Results. Overall, no significant difference was found for the number of rejections, delayed graft function (DGF), functional data (creatinine, creatinine clearance and GFR) or graft survival despite a significant difference in CIT of Rank 1 recipients (8.3 h) vs. Rank 2 recipients (14.3 h). Subgroup analysis of kidneys transplanted in the Eurotransplant Senior Program (CIT Rank 1: 7 h vs. Rank 2: 12 h) also showed no difference for all the items studied. Donor kidneys ≥65 years transplanted at Rank 2 had a higher rate of DGF when compared with kidneys from donors |
| Databáze: | OpenAIRE |
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