COMPARISON OF THYROID ANTIGENS BY THE EXPERIMENTAL PRODUCTION OF PRECIPITATING ANTIBODIES TO HUMAN THYROID FRACTIONS AND THE IDENTIFICATION OF AN ANTIBODY WHICH COMPETES WITH LONG-ACTING THYROID STIMULATOR (LATS) FOR THYROID BINDING
| Autor: | C. von Westarp, Andrew J. S. Knox, Robert Volpé, V. V. Row |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin Cross Reactions Thyroiditis Endocrinology Antigen Antibody Specificity Thyroid peroxidase Internal medicine medicine Chemical Precipitation Humans Antigens Receptor Autoantibodies Antiserum biology Goiter Chemistry Thyroid Thyroiditis Autoimmune General Medicine medicine.disease Thyroid Diseases Graves Disease Long-Acting Thyroid Stimulator medicine.anatomical_structure Immunoglobulin G biology.protein Immunization Binding Sites Antibody Antibody Subcellular Fractions |
| Zdroj: | Acta Endocrinologica. 84:759-767 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0840759 |
| Popis: | Antibodies were raised to various sub-cellular fractions of human thyroids, (of Graves' disease, Hashimoto's thyroiditis, and non-toxic goitre). With one exception it was found that antibodies to the Graves' thyroid fractions cross-reacted with both the non-toxic goitre and Hashimoto's thyroiditis fractions. This exception was in the antiserum to the Graves' 105 000 × g pellet (Gr4) which contained an antibody (A-1) that could not be absorbed by either the non-toxic goitre (NTG) or the Hashimoto's (H) thyroid preparations. The antibody-antigen reaction between A-1 and Gr4 could be blocked by the addition of LATS (or TSH) to the antigen, thus suggesting that A-1 might be a LATS-like immunoglobulin. These results suggest that the TSH receptor may be antigenic and that an antibody to this receptor can be produced in vivo. Production of such an antibody to the TSH receptor would permit the development for the first time of a good animal model of Graves' disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|