Clinical Response to Induction Chemotherapy Predicts Outcome after Combined-Modality Therapy in Inflammatory Breast Cancer
| Autor: | Almudena Maria Cascales-Garcia, Marie-Christine Mathieu, Chafika Mazouni, Sofia Rivera, Ariane Dunant, Rodrigo Arriagada, Mauro Loi, Eric Deutsch, Sahar Ghith, Barbara Pistilli |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Multivariate analysis medicine.medical_treatment Inflammatory breast cancer Disease-Free Survival Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Median follow-up Internal medicine medicine Humans Combined Modality Therapy skin and connective tissue diseases Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Induction chemotherapy Induction Chemotherapy General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Treatment Outcome 030104 developmental biology 030220 oncology & carcinogenesis Cohort Female Inflammatory Breast Neoplasms Neoplasm Grading business |
| Zdroj: | Cancer Investigation. 37:29-38 |
| ISSN: | 1532-4192 0735-7907 |
| Popis: | Purpose To assess predictors of outcome in a cohort of Inflammatory Breast Cancer (IBC) patients receiving induction chemotherapy followed by local treatment. Methods We retrospectively reviewed 95 non-metastatic IBC patient files. Results Complete clinical response (cCR) was obtained in 15 (16%) patients. Median follow up was 13.4 years (IC95%: 10.4-14.6). Loco-regional control (LC), disease-free survival (DFS), and overall survival (OS) at 5 years were 85%, 41%, and 55%, respectively; cCR was associated with better DFS and OS in multivariate analyses adjusted for age (p = 0.02). Conclusions Clinical response to upfront chemotherapy predicts the outcome of patients affected by IBC. |
| Databáze: | OpenAIRE |
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