| Autor: |
Yang Cheng, Hao Zhang, Hui Zheng, Hongli Yin, Ying Wang, Hui Wang, Liubao Gu, Donghua Yin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ open. 12(12) |
| ISSN: |
2044-6055 |
| Popis: |
ObjectiveEvidence suggests that both serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL-C) are risk factors for chronic kidney disease (CKD). The SUA-to-HDL-C ratio (UHR) has recently attracted attention as a new biomarker to evaluate the role between inflammatory and anti-inflammatory substances. Thus, we explored the association between UHR and CKD in a large Chinese population.DesignA cross-sectional study.SettingAnnual health check-up population in Nanjing.Participants19 458 individuals who underwent an annual health check-up in 2019 were included in our study.Main outcome measureCKD was diagnosed according to an estimated glomerular filtration rate (eGFR) 2.ResultsCorrelation analysis showed that UHR was negatively associated with eGFR after adjusting for confounding factors (r=−0.34). In addition, participants in the highest quartile of UHR had a higher risk of CKD than those in the lowest quartiles (OR=9.28, pConclusionWe found that high UHR values were positively associated with CKD risk in health check-up population. An increased UHR may be a useful measure by which to assess CKD risk in the preclinical stage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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