Maspin mRNA expression in sentinel lymph nodes predicts non-SLN metastasis in breast cancer patients with SLN metastasis

Autor:	Yoshihisa Umekita, Akihide Tanimoto, Yasuaki Sagara, Masakazu Souda, Orie Iwaya, Daisuke Yotsumoto, Yasuyo Ohi, Shugo Tamada
Rok vydání:	2018
Předmět:	0301 basic medicine Histology Axillary lymph nodes Lymphovascular invasion Breast Neoplasms Pathology and Forensic Medicine Metastatic carcinoma Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Carcinoma Humans Serpins business.industry Sentinel Lymph Node Biopsy Carcinoma Ductal Breast Maspin General Medicine Middle Aged medicine.disease Prognosis body regions 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer research Female Lymph Sentinel Lymph Node business
Zdroj:	Histopathology. 73(6)
ISSN:	1365-2559
Popis:	AIMS Maspin is known to be a tumour suppressor protein, but its prognostic significance in breast cancer patients is controversial. There is no report focusing on maspin expression in metastatic carcinoma of sentinel lymph nodes (SLNs); we thus investigated maspin mRNA expression in SLNs using the remaining specimens after the one-step nucleic acid amplification (OSNA) assay. METHODS AND RESULTS Ninety-three breast cancer patients with SLNs metastasis detected by the OSNA assay were enrolled. All patients experienced additional axillary lymph nodes (LNs) dissection and all dissected LNs were examined histopathologically. Maspin mRNA expression in SLNs was detected in 49.5% (46 of 93) and was correlated significantly with the presence of non-SLN metastasis (P < 0.0001) and ≥4 LN metastases (P = 0.029). In a multivariate logistic analysis, maspin mRNA expression in SLNs (P = 0.0015) had the most significant effect on predicting non-SLN metastasis, followed by pathological tumour size (P = 0.0039) and lymphovascular invasion (P = 0.009). The status of maspin mRNA expression in SLNs was correlated significantly with that of maspin protein expression in the primary carcinoma (P < 0.0001). CONCLUSIONS This is the first study, to our knowledge, demonstrating that maspin mRNA expression in SLNs is an independent predictor of non-SLN metastasis and the presence of ≥4 LN metastases in breast cancer patients with SLN metastasis. The investigation of maspin mRNA expression in SLNs using the remaining specimens after the OSNA assay may be useful for predicting the further progression of metastatic carcinoma in breast cancer patients with SLNs metastasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb77a0f5ca1aec6e8385ce6ada66fc9 https://pubmed.ncbi.nlm.nih.gov/30035819 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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