Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma
| Autor: | K. Marlicz, Teresa Starzyńska, Stephen A Roberts, Peter L. Stern, Michael Bromley, Michal Ucinski |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Colorectal cancer Rectum Disease Gastroenterology Internal medicine medicine Carcinoma Humans Radical surgery P53 expression Aged Retrospective Studies Hepatology business.industry Retrospective cohort study Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis medicine.anatomical_structure Female Tumor Suppressor Protein p53 Colorectal Neoplasms business Biomarkers |
| Zdroj: | ResearcherID |
| ISSN: | 0954-691X |
| Popis: | Objective: To evaluate the prognostic value of p53 in colorectal cancer. Design: A retrospective study to investigate the correlation between p53 in tumour tissue and the course of patients' disease. Patients: One hundred and two patients who underwent radical surgery for colorectal cancer and were followed up for a minimum of 5 years, or until death, were included in this study. Methods: The p53 expression in tumour tissue was studied by immunohistochemistry using CM1 polyclonal rabbit antibody and formalin-fixed, paraffin-embedded material. Results: p53 accumulation was detected in 46% (47/102) of the tumours. There was no significant difference in long-term survival between the patients with p53 positive and negative tumours (P=0.86). Five-year survival rates were 55% for p53 positive tumours compared with 56% for patients with p53 negative tumours. However, patients with p53 overexpressing tumours showed a higher local recurrence rate than those having carcinomas with undetectable levels of p53, 23% versus 9% respectively ; the 2-year actuarial rates of 26% and 9% were statistically different (P=0.015). Conclusion: The results suggest that in colorectal carcinoma accumulation of p53 is not associated with a difference in long-term prognosis. However, this phenomenon might be useful in the identification of patients with a high risk of local recurrence. |
| Databáze: | OpenAIRE |
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