Transcriptional and epigenetic regulations of embryonic stem cells
| Autor: | Jian-Chien Dominic Heng, Huck-Hui Ng, Jia-Hui Ng, Yuin-Han Loh |
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| Rok vydání: | 2008 |
| Předmět: |
Transcription
Genetic Health Toxicology and Mutagenesis Cellular differentiation Polycomb-Group Proteins Histone-Lysine N-Methyltransferase DNA Methylation Self renewal Biology Embryonic stem cell Epigenesis Genetic Cell biology Repressor Proteins Gene Expression Regulation Histone Methyltransferases Genetics Protein Methyltransferases Epigenetics Stem cell Molecular Biology Cell potency Transcription factor Embryonic Stem Cells Function (biology) |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 647:52-58 |
| ISSN: | 0027-5107 |
| Popis: | Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells. |
| Databáze: | OpenAIRE |
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