Quantitative SPECT/CT parameters of myocardial 99mTechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake in suspected cardiac transthyretin amyloidosis
| Autor: | Jamshed Bomanji, Alexandre Chicheportiche, P M Elliott, E O'Mahoney, E Stern, M Arad, M Smekhov, Simona Ben-Haim, Bella Yuzefovich, Leon Menezes, Elinor Goshen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lung
biology business.industry Amyloidosis R895-920 medicine.disease Amyloid heart disease Image analysis Visual grading Transthyretin Medical physics. Medical radiology. Nuclear medicine medicine.anatomical_structure Cardiac amyloidosis SPECT/CT quantitation SPECT medicine biology.protein Radiology Nuclear Medicine and imaging Ct imaging Nuclear medicine business Cardiac imaging Original Research |
| Zdroj: | EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021) EJNMMI Research |
| Popis: | Background 99mTc-labelled bisphosphonates are used for imaging assessment of patients with transthyretin cardiac amyloidosis (ATTR). Present study evaluates whether quantitative SPECT/CT measurement of absolute myocardial 99mTc-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (Tc-DPD) uptake can diagnose patients with suspected ATTR. Methods Twenty-eight patients (25 male, age 80.03 ± 6.99 years) with suspected ATTR referred for Tc-DPD imaging had planar and SPECT/CT imaging of the chest. Three operators independently obtained Tc-DPD myocardial SUVmax and SUVmean above threshold (SMaT) (20, 40 and 60% of SUVmax), using a semi-automated threshold segmentation method. Results were compared to visual grading (0–3) of cardiac uptake. Results Twenty-two patients (78%) had cardiac uptake (2 grade 1, 15 grade 2, 5 grade 3). SUVmax and SMaT segmentation thresholds enabled separating grades 2/3 from 0/1 with excellent inter- and intra-reader correlation. Cut-off values 6.0, 2.5, 3 and 4 for SUVmax, SMaT20,40,60, respectively, separated between grades 2/3 and 0 /1 with PPV and NPV of 100%. SMaT20,40,60(cardiac)/SUVmean (liver) and SMaT20,40,60(cardiac)/SUVmean(liver/lung) separated grades 2 and 3. Conclusion Quantitative SPECT/CT parameters of cardiac Tc-DPD uptake are robust, enabling separation of patients with grades 2 and 3 cardiac uptake from grades 0 and 1. Larger patient cohorts will determine the incremental value of SPECT/CT quantification for ATTR management. |
| Databáze: | OpenAIRE |
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