Unique change of pancreastatin-like immunoreactivity in cerebrospinal fluid by aging
| Autor: | Masao Ohashi, Ryoichi Takayanagi, Masafumi Haji, Hajime Nawata, Kensaku Sekiya, Masanobu Oyama, Akihiro Funakoshi, Shinnosuke Kurose, Kohei Akazawa, Ryusuke Nakao, Kayoko Tateishi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Aging Specific antiserum medicine.medical_specialty Adolescent Radioimmunoassay Pancreastatin Trypsin like enzyme Cerebrospinal fluid Age groups Internal medicine medicine Humans Endocrine system Aged Aged 80 and over biology Chemistry General Neuroscience fungi food and beverages Chromogranin A Middle Aged Pancreatic Hormones Molecular Weight Endocrinology Chromatography Gel biology.protein Female Antibody |
| Zdroj: | Neuroscience Letters. 170:179-182 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)90268-2 |
| Popis: | Using a specific antiserum for the C-terminal glycine amide region of human pancreastatin (PST), pancreastatin-like immunoreactivity (PST-LI) was measured in cerebrospinal fluid (CSF) from 447 subjects (368 ± 10.8 pmol/l, mean ± S.E.M.) free from endocrine diseases. The CSF contents of PST-LI showed a mountain-shape type change which peaked at 40 years of age. The highest concentration was found in the group of ages 40–49 years old (412 ± 22.9 pmol/l) and the lowest concentration was found in the group of ages 80–89 years old (293.2 ± 45.2 pmol/l) among various age groups. Gel chromatographic examination revealed the presence of two major forms (MW 13,500 and 5,400) of PST-LI in CSF. Because of the character of this antibody, the large molecular form is possibly an N-terminally elongated PST and the other may be PST-52. This may be the first report on the unique age-related change of PST concentration in CSF. |
| Databáze: | OpenAIRE |
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