Ovalicin Ameliorates Compound 48/80-Induced Atopic Dermatitis-Related Symptoms
| Autor: | Ji-Young Jeon, Hyeong-U Son, Myeong-Lyeol Lee, Sung-Hee Nam, Sang-Han Lee, Hei-Sam Lee, Cheol-Sik Yoon |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pharmaceutical Science Metarhizium anisopliae Secondary metabolite Dermatitis Atopic Mice chemistry.chemical_compound Anti-Allergic Agents medicine Animals p-Methoxy-N-methylphenethylamine Mast Cells Pharmacology Mice Inbred BALB C Behavior Animal biology Degranulation General Medicine Atopic dermatitis Compound 48/80 Scratching biology.organism_classification medicine.disease Disease Models Animal chemistry Immunology Entomopathogenic fungus Leukocytes Mononuclear Sesquiterpenes Histamine medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 34:1881-1884 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.34.1881 |
| Popis: | Ovalicin, a secondary metabolite produced by an entomopathogenic fungus Metarhizium anisopliae var. anisopliae, is currently used as an efficient biological control agent against various agricultural insect pests, but not so many biological activities have been investigated. To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. The results revealed that ovalicin significantly reduces scratching behavior in a concentration-dependent fashion. Moreover, the treatment inhibits the levels of the degranulation of mast cells by 65%, and levels of histamine release by 51% at a concentration of 10 µg/ml. Together, the present data strongly suggest that ovalicin elicits potential anti-atopic activities in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|