Effects of Lean Pork on Microbiota and Microbial-Metabolite Trimethylamine-N-Oxide: A Randomized Controlled Non-Inferiority Feeding Trial Based on the Dietary Guidelines for Americans

Autor:	Samitinjaya Dhakal, Zahra Moazzami, Cydne Perry, Moul Dey
Rok vydání:	2022
Předmět:	Swine Microbiota Oxides Poultry Choline Gastrointestinal Microbiome Nutrition Policy Methylamines Red Meat Pork Meat Animals Humans Food Science Biotechnology
Zdroj:	Molecular nutritionfood research. 66(9)
ISSN:	1613-4133
Popis:	Trimethylamine-N-oxide (TMAO) is a microbiota-dependent and primarily animal-protein-derived proatherogenic metabolite. The ecological impact of pork-the most popular animal protein worldwide-on the human microbiome, and in the physiological context of TMAO and other biogenic amines, remains unknown. Poultry being the recommended heart-healthier animal protein, we investigated-if pork intake results in inferior-to-chicken TMAO-response while consuming a diet based on the Dietary Guidelines for Americans (DGA).In a randomized, controlled, all-food-provided, crossover, feeding trial, healthy adults consumed 156 g dayUnlike extrapolating negative results, this study presents noninferiority-testing based evidence. Consuming pork as a predominant protein within an omnivorous DGA-diet does not exacerbate TMAO-response. Results highlight the importance of understanding protein-TMAO interactions within dietary patterns.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb0fe988893d06b7f1603a1cf81cf38 https://pubmed.ncbi.nlm.nih.gov/35182101 Zobrazit plný text záznamu Plný text